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KMID : 1123920060200020388
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 2 p.388 ~ p.393
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Effects of Radix Rosae Laevigatae on the Monosodium Urate(MSU)-induced Gout Model in Rats
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Lee Joo-Ho
Kim Cheol-Jung
Cho Chung-Sik
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Abstract
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The aim was to identify the inhibitory effects of Radix Rosae Laevigatae(RRL) on Monosodium Urate(MSU)-induced gout in rats. After pretreatment of RRL I (125mg/kg), RRL II (50mg/kg) for seven days followed by injection of MSU solution, the various indicators related to gout were measured, such as hematological and serum levels and including joint inflammation. Also, it was investigated whether RRL directly inhibits the activity of xanthine oxidase in vitro. As a result of this study, RRL didn’t show the cytotoxicity on cell proliferation, but it showed significant inhibition of activity of xanthine oxidase in vitro. RRL slightly inhibited joint inflammation induced by MSU though not with statistical significance. RRL partially decreased MSU-induced BUN, creatinine, WBC, ESR elevation and significantly decreased MSU-induced AST, ALT, uric acid in serum. These results suggest that RRL has therapeutic effects that are applicable to prevention and treatment of gout, and should be further investigated.
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KEYWORD
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Gout, Radix Rosae Laevigatae(RRL), Monosodium Urate(MSU), xanthine oxidase(XO)
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